最新評論

mang2004 2020-08-01 01:35

A Self-Evaluating Photothermal Therapeutic Nanoparticle td4*+)'FY  
Abstract lJoMJS;S]}  
Q6Q>b4 .3  
Today, tumor therapy and its therapeutic efficiency evaluation are conducted separately, and current imaging techniques cannot evaluate tumor-therapeutic effects in real time. Therefore, it is of great importance to develop highly efficient theranostic strategies which are able to evaluate their tumor-therapeutic effects in real time. In this work, by rational design of a small molecular near-infrared probe Cys(StBu)-Asp-Glu-Val-Asp-Lys(Cypate)-CBT (Cy-CBT) and using a CBT-Cys click condensation reaction, we facilely prepare an intelligent nanoparticle Cy-CBT-NP which is able to evaluate its photothermal therapy (PTT) efficiency on tumors by fluorescence “Turn-On”. Fluorescence of Cy-CBT-NP is quenched and photothermal responsive. Upon caspase 3 (Casp3) cleavage of its DEVD substrates, Cy-CBT-NP disassembles to turn the fluorescence “On”, which in turn evaluates the PTT efficiency of the nanoparticle on cells and tumors in real time. We envision that our smart strategy could be applied for PTT and real-time evaluation of the therapeutic efficiency of solid tumors in the near future. ]7zDdI|  

dushunli 2020-08-01 03:41

腫瘤光熱治療！

tassy 2020-08-01 04:30

療效實時成像評估!

bmw0501 2020-08-01 08:28

中國科大實現(xiàn)腫瘤光熱治療和療效實時成像評估

tomryo 2020-08-01 08:38

中國科大實現(xiàn)腫瘤光熱治療和療效實時成像評估

木子示羊 2020-08-01 08:53

中國科大實現(xiàn)腫瘤光熱治療和療效實時成像評估

redplum 2020-08-01 09:33

好厲害的成果

likaihit 2020-08-01 09:34

真牛逼啊

wangjin001x 2020-08-01 13:28

中國科大實現(xiàn)腫瘤光熱治療和療效實時成像評估

te67f42 2020-08-01 13:35

中科大與安徽醫(yī)科大合作，發(fā)表了一種有機納米離子用于腫瘤光熱治療及療效實時成像評估的“智能”策略，在腫瘤治療與療效評估一體化方面取得了重要進展。